Refobacin Revision can be mixed both by hand and in a vacuum mixing system. However, Modern Cementing Technique recommends using a vacuum mixing system for mixing and delivery of bone cement, such as the Optivac® system

Modern vacuum mixing systems are designed to ease standardised handling and help to achieve a reproducible, homogeneous bone cement of highest quality^,,

Refobacin Revision is a high viscosity bone cement. In both the Norwegian Arthroplasty Register and the Swedish Hip Arthroplasty Register, the use of high viscosity cements with gentamicin has been shown to result in low incidence of revision^,

Refobacin® Revision exceeds the ASTM F451 and ISO 5833 requirements for bone cement mechanical properties, including compressive strength, bending strength and bending modulus

Gentamicin is bactericidal on proliferating and resisting pathogens and has shown to be the antibiotic of choice for bone cement. With its broad therapeutic spectrum gentamicin covers a wide variety of gram-positive and gram-negative bacteria. Clindamycin has a predominantly bacteriostatic effect on gram-positive bacteria such as staphylococci and streptococci as well as on gram-positive and gram-negative anaerobes.

The combination of clindamycin and gentamicin is an effective antibiotic sensitivity profiles in revisions because most pathogens causing periprosthetic infections have a susceptibility pattern covered by these agents.^,

Antibiotic-loaded bone cement, such as Refobacin Revision, provides effective local concentrations of antibiotics in tissue surrounding the implant

In internal laboratory testing Refobacin Revision has shown to fulfill the internal requirements concerning in-vitro release of gentamicin and clindamycin from the bone cement over several days