Periprosthetic Joint Infection (PJI) is one of the most common complications following total joint arthroplasty, accounting for 25% of total knee arthroplasty failures and 16% of total hip arthroplasty failures.1 As a result, a timely and accurate diagnosis is necessary. Biomarkers such as alpha defensin are used to aid in the diagnosis of PJI.
What is Alpha Defensin?
Alpha Defensin is an antimicrobial peptide released into the body through activated neutrophils in response to an infection. In cases of PJI, a patient will have elevated levels of alpha defensin in their synovial fluid.