Advancing Biofilm Removal
Bactisure Wound Lavage is used with the Zimmer Pulsavac® Plus or Pulsavac Plus AC Wound Lavage Systems, and is indicated for use in cleansing and removal of debris, including micro organisms, from wounds.
- Bactisure Wound Lavage breaks up crosslinks within biofilm EPS.1
- With EPS crosslinks removed, Bactisure Wound Lavage solubilizes biofilms is designed for easy removal via pulsed lavage. Exposed bacteria are subject to lavage removal or inactivation via traditional antibiotics and the body’s normal defense mechanisms.2
Biofilm is a global healthcare problem3,4
of Bacteria are Planktonic/ free-floating3,4
of Bacteria exists in Biofilms structure3,4
Ingredients include ethanol (solvent), acetic acid (pH modifier), sodium acetate (buffering agent), benzalkonium chloride (surfactant), and purified water. Bactisure Wound Lavage is supplied in a 1000ml single-dose flexible plastic container/bag with a sterile fluid path and is packaged with a dust cover.
A New Approach to Biofilm Removal
- Bacteria can produce Extracellular Polymeric Substance (EPS) to shield themselves from both mechanical and chemical attack. Bactisure Wound Lavage was specifically designed to remove these structurally resistant forms of bacteria. Our solution is designed to physically deconstructs the protective EPS matrix, making bacteria more susceptible to traditional antibiotics and the body’s normal defense mechanisms.
Key Application Steps
- Apply just prior to wound closure using Zimmer Biomet Pulsavac Plus pulsed lavage system.
- Immediately after irrigating the wound bed, the wound bed MUST BE rinsed away with an equal amount of normal saline.
Biofilm’s Role in Chronic Wound Infections
- Over 90% of all bacteria exist in biofilms.3
- Biofilms are formed in the body when bacteria coalesce on surface structures and produce an Extracellular Polymeric Substance (EPS). 3,4
- The EPS then shields bacteria from both mechanical and chemical attack. 2,3
- EPS shielded bacteria in a biofilm can be 1000x more resistant to antibiotics than planktonic (free-floating) bacteria. 2,1
- The periodic release of planktonic bacteria from biofilms have been linked to chronic relapsing infections.3
Bactisure™ Wound Lavage - Advancing Biofilm Removal
Contact us for more information
- Dr. Garth James, Montana State University Center for Biofilm Education; Next Science report TR-02-14-025.
- Gupta K, Marques C, Petrova OE, Sauer K. Antimicrobial tolerance of Pseudomonas aeruginosa biofilms is activated during an early developmental stage and requires the two component hybrid sagS. Journal of Bacteriology. 2013;195(21):4975-4987.
- Leid JG, Willson CJ, Shirtliff ME, et al. The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-mediated macrophage killing. J Immunol. 2005;175(11):7512-7518.
- Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999). Bacterial biofilms: a common cause of persistent infections. Science (New York, N.Y.), 284(5418), 1318-22.